Chemotherapeutic Properties of Naturally Occurring Stilbene Polyphenol-Resveratrol

نویسندگان

  • K M Srinivasa Murthy
  • M Narayanappa
  • H Krishna Ram
چکیده

Stilbenes are low molecular weight polyphenols found in many plant species as plant antibiotics and produced in response to infection or stress as plant protectants. Many naturally occurring stilbene compounds like resveratrol (3,5,4‘ trihydroxystilbene) has multi-functional effects such as antioxidant, anti-inflammatory, anti-cancer, and cardio-protectant and recent studies focused on its positive effect on age related infertility problems. It increases vasorelaxation, lowers cholesterol, improves RBC deformability, activates potassium channels, positive effect on myocardial remodeling and inhibits platelet aggregation. Res involves in the prevention and treatment of autoimmune diseases by elevating proteoglycan level. Resveratrol activates anti-aging genes and extends life span in lower organisms. It is also known to exert nueroprotective property. This review article mainly focused on the therapeutic properties of stilbenes, such as resveratrol.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Resveratrol and its Hydroxylated Analogues on Proliferation and Apoptosis of Two Cervix Cancer Derived Cancer Cell Lines. The Role of Mitochondrial Superoxide Dismutase

The naturally occurring polyphenol resveratrol (3,4',5-trihydroxy-stilbene, 3,4',5-THS, RES) has been shown as a chemopreventive and proapototic agent. Resveratrol is extensively metabolized by CYP450 enzymes. The monohydroxylation of resveratrol is catalyzed by CYP1B1 to form 3,3',4',5-THS (piceatannol), a metabolite with higher anticancer activity and stronger antioxidant properties. It was h...

متن کامل

P-28: Effects of Resveratrol on Nicotine Toxicity of The Spermatogenesis of Rats

Background: Nicotine is a major toxic component of cigarette smoke and it is a major risk factor in the development of functional disorder of several organ systems. Resveratrol (trans-3,5,4'-trihydroxystilbene; RES) is a naturally occurring polyphenol synthesized by a variety of plant species in response to injury, UV irradiation and fungal attack. It is present in grapes, berries, peanuts...

متن کامل

Differences in the glucuronidation of resveratrol and pterostilbene: altered enzyme specificity and potential gender differences.

Resveratrol, a natural polyphenol found in grapes, berries and other plants, has been proposed as an ideal chemopreventative agent due to its plethora of health promoting activities. However, despite its lofty promise as a cancer prevention agent its success in human clinical trials has been limited due to its poor bioavailability. Thus, interest in other natural polyphenols is intensifying inc...

متن کامل

Resveratrol and Ophthalmic Diseases.

Resveratrol, a naturally occurring plant polyphenol found in grapes, is the principal biologically active component in red wine. Clinical studies have shown that resveratrol due to its potent anti-oxidant and anti-inflammatory properties are cardio-protective, chemotherapeutic, neuroprotective, and display anti-aging effects. Oxidative stress and inflammation play a critical role in the initiat...

متن کامل

The Role of Resveratrol in Cancer Therapy

Abstract: Natural product compounds have recently attracted significant attention from the scientific community for their potent effects against inflammation-driven diseases, including cancer. A significant amount of research, including preclinical, clinical, and epidemiological studies, has indicated that dietary consumption of polyphenols, found at high levels in cereals, pulses, vegetables, ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015